Sepsis
Resources to Review Prior to Conference
Goals and Objectives
Goals
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Trainee will demonstrate competence in the initial evaluation and basic management of patients with sepsis, severe sepsis and septic shock
Objectives
Trainee will be able to:
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Describe criteria for the following:
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Systemic Inflammatory Response Syndrome (SIRS)
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Sepsis
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Severe Sepsis*
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Septic Shock
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For patients presenting with sepsis, resident will be able to:
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List and describe rationale for initial laboratory and radiology testing including screening for:
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Infectious source
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Metabolic derangement (including lactate)
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End-organ damage
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List and describe indications for early interventions, including:
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Antibiotics (including type)
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IV fluids (including quantity)
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Source control
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List and describe indications for advanced interventions, including:
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Vasopressors
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Inotropes
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Steroids
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Blood transfusion
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* Excluded from Third International Consensus Definitions for Sepsis
Additional Resources
Review Articles
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Severe Sepsis and Septic Shock (NEJM 2013) (pdf)
Landmark Sepsis Publications
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Sepsis-3 (JAMA 2016)
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ProCESS (NEJM 2014)
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ProCESS Review (EMCrit)
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ProCESS Review (PulmCCM)
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ProCESS Review (ALiEM)
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ARISE (NEJM 2014)
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ARISE Review (EMCrit)
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ARISE Review (PulmCCM)
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EGDT / Rivers (NEJM 2001) (pdf)
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Early Warning Scores
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qSOFA as Early Warning Score (Am J Respir Crit Care Med 2016)
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qSOFA Early Warning Score Review (PulmCrit 2016)
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Septic Shock​
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CENSER: Early Norepinephrine in Septic Shock (Am J Respir Crit Care 2019)
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Antibiotics
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Outcome of Early Versus Immediate Antibiotics (Ann Emerg Med 2020)
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Likelihood of Bacterial Infection in Patients Treated With Broad-Spectrum IV Antibiotics in the ED (Crit Care Med 2021)
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Adjunctive Treatments
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VITAMINS: Vitamin C, Hydrocortisone, and Thiamine in Sepsis (JAMA 2020)
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CITRIS-ALI: Vitamin C in Sepsis (JAMA 2019)
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